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Integrating genome-wide polygenic risk scores and non-genetic risk to predict colorectal cancer diagnosis using UK Biobank data: population based cohort study

OBJECTIVE: To evaluate the benefit of combining polygenic risk scores with the QCancer-10 (colorectal cancer) prediction model for non-genetic risk to identify people at highest risk of colorectal cancer. DESIGN: Population based cohort study. SETTING: Data from the UK Biobank study, collected betwe...

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Detalles Bibliográficos
Autores principales:	Briggs, Sarah E W, Law, Philip, East, James E, Wordsworth, Sarah, Dunlop, Malcolm, Houlston, Richard, Hippisley-Cox, Julia, Tomlinson, Ian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BMJ Publishing Group Ltd. 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644277/ https://www.ncbi.nlm.nih.gov/pubmed/36351667 http://dx.doi.org/10.1136/bmj-2022-071707

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