Inhibiting DNA methylation and RNA editing upregulates immunogenic RNA to transform the tumor microenvironment and prolong survival in ovarian cancer

BACKGROUND: Novel therapies are urgently needed for ovarian cancer (OC), the fifth deadliest cancer in women. Preclinical work has shown that DNA methyltransferase inhibitors (DNMTis) can reverse the immunosuppressive tumor microenvironment in OC. Inhibiting DNA methyltransferases activate transcrip...

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Detalles Bibliográficos
Autores principales: Gomez, Stephanie, Cox, Olivia L, Walker, Reddick R, Rentia, Uzma, Hadley, Melissa, Arthofer, Elisa, Diab, Noor, Grundy, Erin E, Kanholm, Tomas, McDonald, James I, Kobyra, Julie, Palmer, Erica, Noonepalle, Satish, Villagra, Alejandro, Leitenberg, David, Bollard, Catherine M, Saunthararajah, Yogen, Chiappinelli, Katherine B
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2022
Materias:
Clinical/Translational Cancer Immunotherapy
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644370/
https://www.ncbi.nlm.nih.gov/pubmed/36343976
http://dx.doi.org/10.1136/jitc-2022-004974

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644370/
https://www.ncbi.nlm.nih.gov/pubmed/36343976
http://dx.doi.org/10.1136/jitc-2022-004974

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