Functionalization of Radiolabeled Antibodies to Enhance Peripheral Clearance for High Contrast Brain Imaging

[Image: see text] Small molecule imaging agents such as [(11)C]PiB, which bind to the core of insoluble amyloid-β (Aβ) fibrils, are useful tools in Alzheimer’s disease (AD) research, diagnostics, and drug development. However, the [(11)C]PiB PET signal saturates early in the disease progression and...

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Detalles Bibliográficos
Autores principales: Schlein, Eva, Syvänen, Stina, Rokka, Johanna, Gustavsson, Tobias, Rossin, Raffaella, Robillard, Marc, Eriksson, Jonas, Sehlin, Dag
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644377/
https://www.ncbi.nlm.nih.gov/pubmed/36201682
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644377/
https://www.ncbi.nlm.nih.gov/pubmed/36201682
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00536

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