Mechanistic Insights into the Activation of Lecithin–Cholesterol Acyltransferase in Therapeutic Nanodiscs Composed of Apolipoprotein A-I Mimetic Peptides and Phospholipids

[Image: see text] The mechanistic details behind the activation of lecithin–cholesterol acyltransferase (LCAT) by apolipoprotein A-I (apoA-I) and its mimetic peptides are still enigmatic. Resolving the fundamental principles behind LCAT activation will facilitate the design of advanced HDL-mimetic t...

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Detalles Bibliográficos
Autores principales: Giorgi, Laura, Niemelä, Akseli, Kumpula, Esa-Pekka, Natri, Ossi, Parkkila, Petteri, Huiskonen, Juha T., Koivuniemi, Artturi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2022
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644404/
https://www.ncbi.nlm.nih.gov/pubmed/36111986
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644404/
https://www.ncbi.nlm.nih.gov/pubmed/36111986
http://dx.doi.org/10.1021/acs.molpharmaceut.2c00540

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