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Myeloma immunoglobulin rearrangement and translocation detection through targeted capture sequencing

Multiple myeloma is a plasma cell neoplasm characterized by clonal immunoglobulin V(D)J signatures and oncogenic immunoglobulin gene translocations. Additional subclonal genomic changes are acquired with myeloma progression and therapeutic selection. PCR-based methods to detect V(D)J rearrangements...

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Detalles Bibliográficos
Autores principales: Chow, Signy, Kis, Olena, Mulder, David T, Danesh, Arnavaz, Bruce, Jeff, Wang, Ting Ting, Reece, Donna, Bhalis, Nizar, Neri, Paola, Sabatini, Peter JB, Keats, Jonathan, Trudel, Suzanne, Pugh, Trevor J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644417/
https://www.ncbi.nlm.nih.gov/pubmed/36328595
http://dx.doi.org/10.26508/lsa.202201543