Cargando…
Elevation of spermine remodels immunosuppressive microenvironment through driving the modification of PD-L1 in hepatocellular carcinoma
BACKGROUND: Spermine is frequently elevated in tumor tissues and body fluids of cancer patients and is critical for cancer cell proliferation, migration and invasion. However, the immune functions of spermine in hepatocellular carcinoma progression remains unknown. In the present study, we aimed to...
Autores principales: | Shi, Hong-Xiang, Liang, Chao, Yao, Chao-Yan, Gao, Zi-Xuan, Qin, Jia, Cao, Jin-Lan, Zhang, Ming-Zhu, Li, Ying-Ying, Wang, Meng-Qing, Sun, Hua, Xie, Song-Qiang, Fang, Dong |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644467/ https://www.ncbi.nlm.nih.gov/pubmed/36348350 http://dx.doi.org/10.1186/s12964-022-00981-6 |
Ejemplares similares
-
PKM2 Drives Hepatocellular Carcinoma Progression by Inducing Immunosuppressive Microenvironment
por: Li, Tian-En, et al.
Publicado: (2020) -
Obesity contributes to hepatocellular carcinoma development via immunosuppressive microenvironment remodeling
por: Yang, Jian, et al.
Publicado: (2023) -
Elevated peripheral blood neutrophil-to-lymphocyte ratio is associated with an immunosuppressive tumour microenvironment and decreased benefit of PD-1 antibody in advanced gastric cancer
por: Ruan, Dan-Yun, et al.
Publicado: (2021) -
Deregulated bile acids may drive hepatocellular carcinoma metastasis by inducing an immunosuppressive microenvironment
por: Xia, Jin-kun, et al.
Publicado: (2022) -
d-lactate modulates M2 tumor-associated macrophages and remodels immunosuppressive tumor microenvironment for hepatocellular carcinoma
por: Han, Shulan, et al.
Publicado: (2023)