Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy

BACKGROUND: We reported that PARP-1 regulates genes whose products are crucial for asthma, in part, by controlling STAT6 integrity speculatively through a calpain-dependent mechanism. We wished to decipher the PARP-1/STAT6 relationship in the context of intracellular trafficking and promoter occupan...

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Detalles Bibliográficos
Autores principales: Wang, Jeffrey, Ghonim, Mohamed A., Ibba, Salome V., Luu, Hanh H., Aydin, Yucel, Greer, Peter A., Boulares, A. Hamid
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644602/
https://www.ncbi.nlm.nih.gov/pubmed/36348405
http://dx.doi.org/10.1186/s12967-022-03715-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644602/
https://www.ncbi.nlm.nih.gov/pubmed/36348405
http://dx.doi.org/10.1186/s12967-022-03715-x

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