The Ca(V)1.2 G406R mutation decreases synaptic inhibition and alters L-type Ca(2+) channel-dependent LTP at hippocampal synapses in a mouse model of Timothy Syndrome

Genetic alterations in autism spectrum disorders (ASD) frequently disrupt balance between synaptic excitation and inhibition and alter plasticity in the hippocampal CA1 region. Individuals with Timothy Syndrome (TS), a genetic disorder caused by Ca(V)1.2 L-type Ca(2+) channel (LTCC) gain-of function...

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Detalles Bibliográficos
Autores principales: Sanderson, Jennifer L., Freund, Ronald K., Castano, Anna M., Benke, Timothy A., Dell’Acqua, Mark L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644825/
https://www.ncbi.nlm.nih.gov/pubmed/36162529
http://dx.doi.org/10.1016/j.neuropharm.2022.109271

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644825/
https://www.ncbi.nlm.nih.gov/pubmed/36162529
http://dx.doi.org/10.1016/j.neuropharm.2022.109271

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