Slower diffusion and anomalous association of R453W lamin A protein alter nuclear architecture in AD-EDMD

Lamins maintain the shape and rigidity of the nucleus in the form of a proteinaceous scaffold underneath the inner nuclear membrane (INM) and provide anchorage to chromatin and other nuclear proteins. Mutations in the human LMNA gene encoding lamin A/C cause about 16 different diseases with distinct...

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Detalles Bibliográficos
Autores principales: Mukherjee, Chandrayee, Sengupta, Duhita, Maganti, Lakshmi, Mahendar, M., Bhattacharyya, Dhananjay, Sengupta, Kaushik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644913/
https://www.ncbi.nlm.nih.gov/pubmed/36415558
http://dx.doi.org/10.1039/d2ra05620h

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9644913/
https://www.ncbi.nlm.nih.gov/pubmed/36415558
http://dx.doi.org/10.1039/d2ra05620h

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