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Structural consequences of sequence variation in mammalian prion β2α2 loop segments

Sequence variation in the β2α2 loop, residues 165-175 of the mammalian prion protein (PrP), influences its structure. To better understand the consequences of sequence variation in this region of the protein, we biochemically and biophysically interrogate natural and artificial sequence variants of...

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Detalles Bibliográficos
Autores principales: Glynn, Calina, Hernandez, Evelyn, Gallagher-Jones, Marcus, Miao, Jennifer, Sigurdson, Christina J., Rodriguez, Jose A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645039/
https://www.ncbi.nlm.nih.gov/pubmed/36389229
http://dx.doi.org/10.3389/fnins.2022.960322