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Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ(42) oligomers by controlling their interactions with cell membranes

The misfolded proteins or polypeptides commonly observed in neurodegenerative diseases, including Alzheimer's disease (AD), are promising drug targets for developing therapeutic agents. To target the amyloid-β (Aβ) peptide plaques and oligomers, the hallmarks of AD, we have developed twelve amp...

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Detalles Bibliográficos
Autores principales: Yu, Zhengxin, Guo, Weijie, Patel, Shrey, Cho, Hong-Jun, Sun, Liang, Mirica, Liviu M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645390/
https://www.ncbi.nlm.nih.gov/pubmed/36519059
http://dx.doi.org/10.1039/d2sc02654f