Cargando…
Amphiphilic stilbene derivatives attenuate the neurotoxicity of soluble Aβ(42) oligomers by controlling their interactions with cell membranes
The misfolded proteins or polypeptides commonly observed in neurodegenerative diseases, including Alzheimer's disease (AD), are promising drug targets for developing therapeutic agents. To target the amyloid-β (Aβ) peptide plaques and oligomers, the hallmarks of AD, we have developed twelve amp...
Autores principales: | Yu, Zhengxin, Guo, Weijie, Patel, Shrey, Cho, Hong-Jun, Sun, Liang, Mirica, Liviu M. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
The Royal Society of Chemistry
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645390/ https://www.ncbi.nlm.nih.gov/pubmed/36519059 http://dx.doi.org/10.1039/d2sc02654f |
Ejemplares similares
-
Structural conversion of neurotoxic amyloid-β(1–42) oligomers to fibrils
por: Ahmed, Mahiuddin, et al.
Publicado: (2010) -
Lysosomal Enzyme Glucocerebrosidase Protects against Aβ(1-42) Oligomer-Induced Neurotoxicity
por: Choi, Seulah, et al.
Publicado: (2015) -
Reversibility of Aβ oligomer neurotoxicity
por: Araki, Wataru
Publicado: (2017) -
Interaction of Aβ42 with Membranes Triggers the Self-Assembly into Oligomers
por: Banerjee, Siddhartha, et al.
Publicado: (2020) -
Aβ42 oligomer-specific antibody ALZ-201 reduces the neurotoxicity of Alzheimer’s disease brain extracts
por: Sandberg, Anders, et al.
Publicado: (2022)