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Cryo-EM structures of peripherin-2 and ROM1 suggest multiple roles in photoreceptor membrane morphogenesis

Mammalian peripherin-2 (PRPH2) and rod outer segment membrane protein 1 (ROM1) are retina-specific tetraspanins that partake in the constant renewal of stacked membrane discs of photoreceptor cells that enable vision. Here, we present single-particle cryo–electron microscopy structures of solubilize...

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Detalles Bibliográficos
Autores principales: El Mazouni, Dounia, Gros, Piet
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645710/
https://www.ncbi.nlm.nih.gov/pubmed/36351012
http://dx.doi.org/10.1126/sciadv.add3677