Heightened apoptotic priming of vascular cells across tissues and life span predisposes them to cancer therapy–induced toxicities

Although major organ toxicities frequently arise in patients treated with cytotoxic or targeted cancer therapies, the mechanisms that drive them are poorly understood. Here, we report that vascular endothelial cells (ECs) are more highly primed for apoptosis than parenchymal cells across many adult...

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Detalles Bibliográficos
Autores principales: Spetz, Johan K. E., Florido, Mary H. C., Fraser, Cameron S., Qin, Xingping, Choiniere, Jonathan, Yu, Stacey J., Singh, Rumani, Friesen, Max, Rubin, Lee L., Salem, Joe-Elie, Moslehi, Javid J., Sarosiek, Kristopher A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645721/
https://www.ncbi.nlm.nih.gov/pubmed/36351019
http://dx.doi.org/10.1126/sciadv.abn6579

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645721/
https://www.ncbi.nlm.nih.gov/pubmed/36351019
http://dx.doi.org/10.1126/sciadv.abn6579

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