CK2-mediated phosphorylation of SUZ12 promotes PRC2 function by stabilizing enzyme active site

Polycomb repressive complex 2 (PRC2) plays a key role in maintaining cell identity during differentiation. Methyltransferase activity of PRC2 on histone H3 lysine 27 is regulated by diverse cellular mechanisms, including posttranslational modification. Here, we report a unique phosphorylation-depend...

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Detalles Bibliográficos
Autores principales: Gong, Lihu, Liu, Xiuli, Jiao, Lianying, Yang, Xin, Lemoff, Andrew, Liu, Xin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645763/
https://www.ncbi.nlm.nih.gov/pubmed/36351927
http://dx.doi.org/10.1038/s41467-022-34431-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645763/
https://www.ncbi.nlm.nih.gov/pubmed/36351927
http://dx.doi.org/10.1038/s41467-022-34431-1

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