Therapeutic resistance in acute myeloid leukemia cells is mediated by a novel ATM/mTOR pathway regulating oxidative phosphorylation

While leukemic cells are susceptible to various therapeutic insults, residence in the bone marrow microenvironment typically confers protection from a wide range of drugs. Thus, understanding the unique molecular changes elicited by the marrow is of critical importance toward improving therapeutic o...

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Detalles Bibliográficos
Autores principales: Park, Hae J, Gregory, Mark A, Zaberezhnyy, Vadym, Goodspeed, Andrew, Jordan, Craig T, Kieft, Jeffrey S, DeGregori, James
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645811/
https://www.ncbi.nlm.nih.gov/pubmed/36259537
http://dx.doi.org/10.7554/eLife.79940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645811/
https://www.ncbi.nlm.nih.gov/pubmed/36259537
http://dx.doi.org/10.7554/eLife.79940

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