Modulating the microenvironment during FVIII uptake influences the nature of FVIII-peptides presented by antigen-presenting cells

BACKGROUND AND AIMS: Hemophilia A is a severe bleeding disorder caused by the deficiency of functionally active coagulation factor VIII (FVIII). The induction of neutralizing anti-drug antibodies is a major complication in the treatment of hemophilia A patients with FVIII replacement therapies. Why...

Descripción completa

Detalles Bibliográficos
Autores principales: Lubich, Christian, Steinitz, Katharina Nora, Hoelbl, Brigitte, Prenninger, Thomas, van Helden, Pauline Maria, Weiller, Markus, Reipert, Birgit Maria
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645812/
https://www.ncbi.nlm.nih.gov/pubmed/36389737
http://dx.doi.org/10.3389/fimmu.2022.975680

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9645812/
https://www.ncbi.nlm.nih.gov/pubmed/36389737
http://dx.doi.org/10.3389/fimmu.2022.975680

Ejemplares similares