Cargando…

Determination of potential thresholds for N-ethyl-N-nitrosourea and ethyl methanesulfonate based on a multi-endpoint genotoxicity assessment platform in rats

The main goal of the study was to investigate the genotoxic response of N-ethyl-N-nitrosourea (ENU) and ethyl methanesulfonate (EMS) at low doses in a multi-endpoint genotoxicity assessment platform in rats and to derive potential thresholds and related metrics. Male Sprague–Dawley rats were treated...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhu, Xuejiao, Huo, Jiao, Zeng, Zhu, Liu, Yunjie, Li, Ruirui, Chen, Yiyi, Zhang, Lishi, Chen, Jinyao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646607/ https://www.ncbi.nlm.nih.gov/pubmed/35793016 http://dx.doi.org/10.1007/s11356-022-21605-z

Ejemplares similares

Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
por: Li, Zhiguang, et al.
Publicado: (2010)

Studies on N-Ethyl-N-nitrosourea Mutagenesis in BALB/c Mice
por: Cho, Kyu-Hyuk, et al.
Publicado: (2008)

The multipotential carcinogenic action of N-ethyl-N-nitrosourea administered neonatally to mice.
por: Searle, C. E., et al.
Publicado: (1976)

N -Ethyl- N -Nitrosourea Induces Retinal Photoreceptor Damage in Adult Rats
por: Yoshizawa, Katsuhiko, et al.
Publicado: (2012)

Longitudinal Evaluation of an N-Ethyl-N-Nitrosourea-Created Murine Model with Normal Pressure Hydrocephalus
por: Lee, Ming-Jen, et al.
Publicado: (2009)

Proceedings: Strain differences in the carcinogenic action of N-ethyl-N-nitrosourea (ENU) in mice.
por: Searle, C. E., et al.
Publicado: (1974)

Studies on the Small Body Size Mouse Developed by Mutagen N-Ethyl-N-nitrosourea
por: Zhang, QianKun, et al.
Publicado: (2008)

Mutational Analysis of N-Ethyl-N-Nitrosourea (ENU) in the Fission Yeast Schizosaccharomyces pombe
por: Hoyos-Manchado, Rafael, et al.
Publicado: (2020)

Spontaneous inflammatory pain model from a mouse line with N-ethyl-N-nitrosourea mutagenesis
por: Chen, Tsung-Chieh, et al.
Publicado: (2012)

Exposure to N-Ethyl-N-Nitrosourea in Adult Mice Alters Structural and Functional Integrity of Neurogenic Sites
por: Capilla-Gonzalez, Vivian, et al.
Publicado: (2012)

High Susceptibility of Analbuminemic Rats to Neurogenic Tumor Induction by Transplacental Administration of N‐Ethyl‐N‐nitrosourea
por: Usuki, Seigou, et al.
Publicado: (1992)

Modulation of autoimmune diabetes by N-ethyl-N-nitrosourea- induced mutations in non-obese diabetic mice
por: Chatenoud, Lucienne, et al.
Publicado: (2022)

N-ethyl-N-nitrosourea mutagenesis produced a small number of mice with altered plasma electrolyte levels
por: Aigner, Bernhard, et al.
Publicado: (2009)

Chromoanasynthetic Genomic Rearrangement Identified in a N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Screen in Caenorhabditis elegans
por: Itani, Omar A., et al.
Publicado: (2015)

Genotoxic Effects of Etoposide, Bleomycin, and Ethyl Methanesulfonate on Cultured CHO Cells: Analysis by GC-MS/MS and Comet Assay
por: Atha, Donald H., et al.
Publicado: (2020)

[1-(1-Adamantylamino)ethylidene]oxonium methanesulfonate
por: Vícha, Robert, et al.
Publicado: (2009)

An N‐Ethyl‐N‐Nitrosourea (ENU) Mutagenized Mouse Model for Autosomal Dominant Nonsyndromic Kyphoscoliosis Due to Vertebral Fusion
por: Esapa, Christopher T, et al.
Publicado: (2018)

Brahmarasayana protects against Ethyl methanesulfonate or Methyl methanesulfonate induced chromosomal aberrations in mouse bone marrow cells
por: Guruprasad, Kanive Parashiva, et al.
Publicado: (2012)

Elevated ethyl methanesulfonate (EMS) in nelfinavir mesylate (Viracept(®), Roche): overview
por: Pozniak, Anton, et al.
Publicado: (2009)

Generating homozygous mutant populations of barley microspores by ethyl methanesulfonate treatment
por: Huang, Linli, et al.
Publicado: (2023)

A monogenic dominant mutation in Rom1 generated by N-ethyl-N-nitrosourea mutagenesis causes retinal degeneration in mice
por: Sato, Hajime, et al.
Publicado: (2010)

An N-Ethyl-N-Nitrosourea (ENU)-Induced Dominant Negative Mutation in the JAK3 Kinase Protects against Cerebral Malaria
por: Bongfen, Silayuv E., et al.
Publicado: (2012)

An N-Ethyl-N-Nitrosourea Induced Corticotropin-Releasing Hormone Promoter Mutation Provides a Mouse Model for Endogenous Glucocorticoid Excess
por: Bentley, Liz, et al.
Publicado: (2014)

N-ethyl-N-Nitrosourea (ENU) Induced Mutations within the Klotho Gene Lead to Ectopic Calcification and Reduced Lifespan in Mouse Models
por: Esapa, Christopher T., et al.
Publicado: (2015)

N-Ethyl-N-Nitrosourea (ENU) Mutagenesis Reveals an Intronic Residue Critical for Caenorhabditis elegans 3′ Splice Site Function in Vivo
por: Itani, Omar A., et al.
Publicado: (2016)

N-Ethyl-n-Nitrosourea Induced Leukaemia in a Mouse Model through Upregulation of Vascular Endothelial Growth Factor and Evading Apoptosis
por: Aliyu, Abdullahi, et al.
Publicado: (2020)

Evaluation of the cytotoxic, anticancer, and genotoxic activities of Acacia nilotica flowers and their effects on N-methyl-N-nitrosourea-induced genotoxicity in mice
por: Diab, Kawthar A., et al.
Publicado: (2022)

An L314Q mutation in Map3k1 gene results in failure of eyelid fusion in the N-ethyl-N-nitrosourea-induced mutant line
por: Chen, Bing, et al.
Publicado: (2021)

Hirschsprung disease is associated with an L286P mutation in the fifth transmembrane domain of the endothelin-B receptor in the N-ethyl-N-nitrosourea-induced mutant line
por: Chen, Bing, et al.
Publicado: (2016)

Protective Effect of Caffeine on Ethyl Methanesulfonate-Induced Wing Primordial Cells of Drosophila Melanogaster
por: Prakash, G., et al.
Publicado: (2014)

Genome‐wide survey of artificial mutations induced by ethyl methanesulfonate and gamma rays in tomato
por: Shirasawa, Kenta, et al.
Publicado: (2015)

Molecular and Biochemical Evaluation of Ethyl Methanesulfonate-Induced Mutant Lines in Camelina sativa L.
por: Kiani, Samira, et al.
Publicado: (2022)

Low Level Determinations of Methyl Methanesulfonate and Ethyl Methanesulfonate Impurities in Emtricitabine Active Pharmaceutical Ingredient by LC/MS/MS Using Electrospray Ionization
por: Kakadiya, P.R., et al.
Publicado: (2011)

Sublinear response in lacZ mutant frequency of Muta(™)Mouse spermatogonial stem cells after low dose subchronic exposure to N‐ethyl‐N‐nitrosourea
por: O'Brien, Jason M., et al.
Publicado: (2015)

Genome-Wide Analysis of Artificial Mutations Induced by Ethyl Methanesulfonate in the Eggplant (Solanum melongena L.)
por: Xiao, Xi-ou, et al.
Publicado: (2019)

artMAP: A user‐friendly tool for mapping ethyl methanesulfonate‐induced mutations in Arabidopsis
por: Javorka, Peter, et al.
Publicado: (2019)

[N-(2-Hydroxyethyl)ethylenediamine]oxalatocopper(II)
por: Paşaoğlu, Hümeyra, et al.
Publicado: (2009)

Enhancement by O6-benzyl-N2-acetylguanosine of N'-[2-chloroethyl]-N-[2-(methylsulphonyl)ethyl]-N'-nitrosourea therapeutic index on nude mice bearing resistant human melanoma.
por: Debiton, E., et al.
Publicado: (1997)

A Mouse with an N-Ethyl-N-Nitrosourea (ENU) Induced Trp589Arg Galnt3 Mutation Represents a Model for Hyperphosphataemic Familial Tumoural Calcinosis
por: Esapa, Christopher T., et al.
Publicado: (2012)

N-Ethyl-N-phenyl-N′-tosylformamidine
por: Shen, Heng-Shui, et al.
Publicado: (2009)

Cannot write session to /tmp/vufind_sessions/sess_vvk3gu6b26clpo9o1s0cnmb8iq