Cargando…
Genomic analysis of early-stage lung cancer reveals a role for TP53 mutations in distant metastasis
Patients with non-small cell lung cancer (NSCLC) who have distant metastases have a poor prognosis. To determine which genomic factors of the primary tumor are associated with metastasis, we analyzed data from 759 patients originally diagnosed with stage I–III NSCLC as part of the AACR Project GENIE...
Autores principales: | Van Egeren, Debra, Kohli, Khushi, Warner, Jeremy L., Bedard, Philippe L., Riely, Gregory, Lepisto, Eva, Schrag, Deborah, LeNoue-Newton, Michele, Catalano, Paul, Kehl, Kenneth L., Michor, Franziska |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646734/ https://www.ncbi.nlm.nih.gov/pubmed/36351964 http://dx.doi.org/10.1038/s41598-022-21448-1 |
Ejemplares similares
-
Correlation Between Surrogate End Points and Overall Survival in a Multi-institutional Clinicogenomic Cohort of Patients With Non–Small Cell Lung or Colorectal Cancer
por: Kehl, Kenneth L., et al.
Publicado: (2021) -
A Scalable Quality Assurance Process for Curating Oncology Electronic Health Records: The Project GENIE Biopharma Collaborative Approach
por: Lavery, Jessica A., et al.
Publicado: (2022) -
Fitness variation in isogenic populations leads to a novel evolutionary mechanism for crossing fitness valleys
por: Van Egeren, Debra, et al.
Publicado: (2018) -
The GENIE BPC NSCLC Cohort: A Real-World Repository Integrating Standardized Clinical and Genomic Data for 1,846 Patients with Non–Small Cell Lung Cancer
por: Choudhury, Noura J., et al.
Publicado: (2023) -
Mitigating the Risk of t-MNs Development: TP53 or Not TP53?
por: Tesio, Melania
Publicado: (2023)