Identification of TFPI as a receptor reveals recombination-driven receptor switching in Clostridioides difficile toxin B variants

Toxin B (TcdB) is a major exotoxin responsible for diseases associated with Clostridioides difficile infection. Its sequence variations among clinical isolates may contribute to the difficulty in developing effective therapeutics. Here, we investigate receptor-binding specificity of major TcdB subty...

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Detalles Bibliográficos
Autores principales: Tian, Songhai, Xiong, Xiaozhe, Zeng, Ji, Wang, Siyu, Tremblay, Benjamin Jean-Marie, Chen, Peng, Chen, Baohua, Liu, Min, Chen, Pengsheng, Sheng, Kuanwei, Zeve, Daniel, Qi, Wanshu, Breault, David T., Rodríguez, César, Gerhard, Ralf, Jin, Rongsheng, Doxey, Andrew C., Dong, Min
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646764/
https://www.ncbi.nlm.nih.gov/pubmed/36351897
http://dx.doi.org/10.1038/s41467-022-33964-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646764/
https://www.ncbi.nlm.nih.gov/pubmed/36351897
http://dx.doi.org/10.1038/s41467-022-33964-9

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