Discovery of potential natural dihydroorotate dehydrogenase inhibitors and their synergism with brequinar via integrated molecular docking, dynamic simulations and in vitro approach

The critical function of dihydroorotate dehydrogenase (DHODH) in pyrimidine synthesis attracted a great interest throughout beyond decades. Inhibitors of human DHODH (hDHODH) have validated efficacy for remedy of many immunological diseases. Brequinar and leflunomide are examples of such compounds....

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Detalles Bibliográficos
Autores principales: Khairy, Asmaa, Hammoda, Hala M., Celik, Ismail, Zaatout, Hala H., Ibrahim, Reham S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646789/
https://www.ncbi.nlm.nih.gov/pubmed/36351991
http://dx.doi.org/10.1038/s41598-022-23006-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646789/
https://www.ncbi.nlm.nih.gov/pubmed/36351991
http://dx.doi.org/10.1038/s41598-022-23006-1

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