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Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids

Disturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). Disruption...

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Detalles Bibliográficos
Autores principales: Natarajaseenivasan, Kalimuthusamy, Garcia, Alvaro, Velusamy, Prema, Shanmughapriya, Santhanam, Langford, Dianne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646946/
https://www.ncbi.nlm.nih.gov/pubmed/36389000
http://dx.doi.org/10.1016/j.isci.2022.105407