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Citrate shuttling in astrocytes is required for processing cocaine-induced neuron-derived excess peroxidated fatty acids
Disturbances in lipid metabolism in the CNS contribute to neurodegeneration and cognitive impairments. Through tight metabolic coupling, astrocytes provide energy to neurons by delivering lactate and cholesterol and by taking up and processing neuron-derived peroxidated fatty acids (pFA). Disruption...
Autores principales: | Natarajaseenivasan, Kalimuthusamy, Garcia, Alvaro, Velusamy, Prema, Shanmughapriya, Santhanam, Langford, Dianne |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646946/ https://www.ncbi.nlm.nih.gov/pubmed/36389000 http://dx.doi.org/10.1016/j.isci.2022.105407 |
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