Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway

Cetuximab is a monoclonal antibody against epidermal growth factor receptor that blocks downstream signaling pathways of receptor tyrosine kinases, including Ras/Raf/MAPK and PI3K/Akt, thereby inhibiting tumor cell proliferation and inducing cancer cell apoptosis. Owing to KRAS mutations, the effect...

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Detalles Bibliográficos
Autores principales: Liu, Yanfei, Tian, Shifeng, Yi, Ben, Feng, Zhiqiang, Chu, Tianhao, Liu, Jun, Zhang, Chunze, Zhang, Shiwu, Wang, Yijia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646952/
https://www.ncbi.nlm.nih.gov/pubmed/36387129
http://dx.doi.org/10.3389/fonc.2022.1046143

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646952/
https://www.ncbi.nlm.nih.gov/pubmed/36387129
http://dx.doi.org/10.3389/fonc.2022.1046143

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