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Platycodin D sensitizes KRAS-mutant colorectal cancer cells to cetuximab by inhibiting the PI3K/Akt signaling pathway
Cetuximab is a monoclonal antibody against epidermal growth factor receptor that blocks downstream signaling pathways of receptor tyrosine kinases, including Ras/Raf/MAPK and PI3K/Akt, thereby inhibiting tumor cell proliferation and inducing cancer cell apoptosis. Owing to KRAS mutations, the effect...
Autores principales: | Liu, Yanfei, Tian, Shifeng, Yi, Ben, Feng, Zhiqiang, Chu, Tianhao, Liu, Jun, Zhang, Chunze, Zhang, Shiwu, Wang, Yijia |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646952/ https://www.ncbi.nlm.nih.gov/pubmed/36387129 http://dx.doi.org/10.3389/fonc.2022.1046143 |
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