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Structural insights into conformational stability and binding of thiazolo-[2,3-b] quinazolinone derivatives with EGFR-TKD and in-vitro study

Heterocyclic molecules are well-known drugs against various diseases including cancer. Many tyrosine kinase inhibitors including erlotinib, osimertinib, and sunitinib were developed and approved but caused adverse effects among treated patients. Which prevents them from being used as cancer therapeu...

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Detalles Bibliográficos
Autores principales: Ahmad Mir, Showkat, Paramita Mohanta, Prajna, Kumar Meher, Rajesh, baitharu, Iswar, Kumar Raval, Mukesh, Kumar Behera, Ajaya, Nayak, Binata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9646979/
https://www.ncbi.nlm.nih.gov/pubmed/36389208
http://dx.doi.org/10.1016/j.sjbs.2022.103478