rAAV immunogenicity, toxicity, and durability in 255 clinical trials: A meta-analysis

Recombinant Adeno-associated virus (rAAV) is one of the main delivery vectors for gene therapy. To assess immunogenicity, toxicity, and features of AAV gene therapy in clinical settings, a meta-analysis of 255 clinical trials was performed. A total of 7,289 patients are planned to be dosed. AAV2 was...

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Detalles Bibliográficos
Autores principales: Shen, Weiran, Liu, Shengjiang, Ou, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647052/
https://www.ncbi.nlm.nih.gov/pubmed/36389770
http://dx.doi.org/10.3389/fimmu.2022.1001263

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647052/
https://www.ncbi.nlm.nih.gov/pubmed/36389770
http://dx.doi.org/10.3389/fimmu.2022.1001263

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