Dual checkpoint blockade of CD47 and LILRB1 enhances CD20 antibody-dependent phagocytosis of lymphoma cells by macrophages

Antibody-dependent cellular phagocytosis (ADCP) by macrophages, an important effector function of tumor targeting antibodies, is hampered by ‘Don´t Eat Me!’ signals such as CD47 expressed by cancer cells. Yet, human leukocyte antigen (HLA) class I expression may also impair ADCP by engaging leukocyt...

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Detalles Bibliográficos
Autores principales: Zeller, Tobias, Lutz, Sebastian, Münnich, Ira A., Windisch, Roland, Hilger, Patricia, Herold, Tobias, Tahiri, Natyra, Banck, Jan C., Weigert, Oliver, Moosmann, Andreas, von Bergwelt-Baildon, Michael, Flamann, Cindy, Bruns, Heiko, Wichmann, Christian, Baumann, Niklas, Valerius, Thomas, Schewe, Denis M., Peipp, Matthias, Rösner, Thies, Humpe, Andreas, Kellner, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647079/
https://www.ncbi.nlm.nih.gov/pubmed/36389667
http://dx.doi.org/10.3389/fimmu.2022.929339

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647079/
https://www.ncbi.nlm.nih.gov/pubmed/36389667
http://dx.doi.org/10.3389/fimmu.2022.929339

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