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A study of the heat-mediated phase transformations of praziquantel hydrates. Evaluation of their impact on the dissolution rate

Comprehensive knowledge of the critical properties of the active pharmaceutical ingredients is a requirement within the modern concept of quality. Praziquantel hemihydrate (HH) and monohydrate (MH) are new solid forms of this antihelmintic agent, which have better solubility properties than the comm...

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Detalles Bibliográficos
Autores principales: Salazar-Rojas, Duvernis, Kaufman, Teodoro S., Maggio, Rubén M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647200/
https://www.ncbi.nlm.nih.gov/pubmed/36387505
http://dx.doi.org/10.1016/j.heliyon.2022.e11317