Cytosolic and mitochondrial tRNA synthetase inhibitors increase lifespan in a GCN4/atf-4-dependent manner

Deletion of genes encoding ribosomal proteins extends lifespan in yeast. This increases translation of the functionally conserved transcription factor Gcn4, and lifespan extension in these mutants is GCN4-dependent. Gcn4 is also translationally upregulated by uncharged tRNAs, as are its Caenorhabdit...

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Detalles Bibliográficos
Autores principales: Robbins, Christine E., Patel, Bhumil, Sawyer, Danielle L., Wilkinson, Barrie, Kennedy, Brian K., McCormick, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647507/
https://www.ncbi.nlm.nih.gov/pubmed/36388960
http://dx.doi.org/10.1016/j.isci.2022.105410

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647507/
https://www.ncbi.nlm.nih.gov/pubmed/36388960
http://dx.doi.org/10.1016/j.isci.2022.105410

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