Exploration of the regulatory relationship between KRAB-Zfp clusters and their target transposable elements via a gene editing strategy at the cluster specific linker-associated sequences by CRISPR-Cas9

BACKGROUND: Krüppel Associated Box-containing Zinc Finger Proteins (KRAB-ZFPs), representing the largest superfamily of transcription factors in mammals, are predicted to primarily target and repress transposable elements (TEs). It is challenging to dissect the distinct functions of these transcript...

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Detalles Bibliográficos
Autores principales: Zhang, Yang, He, Fei, Zhang, Yanning, Dai, Qian, Li, Qintong, Nan, Jing, Miao, Ruidong, Cheng, Bo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647903/
https://www.ncbi.nlm.nih.gov/pubmed/36357895
http://dx.doi.org/10.1186/s13100-022-00279-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647903/
https://www.ncbi.nlm.nih.gov/pubmed/36357895
http://dx.doi.org/10.1186/s13100-022-00279-x

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