Dysregulation of neuroprotective astrocytes, a spectrum of microglial activation states, and altered hippocampal neurogenesis are revealed by single-cell RNA sequencing in prion disease

Prion diseases are neurodegenerative disorders with long asymptomatic incubation periods, followed by a rapid progression of cognitive and functional decline culminating in death. The complexity of intercellular interactions in the brain is challenging to unravel and the basis of disease pathobiolog...

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Detalles Bibliográficos
Autores principales: Slota, Jessy A., Sajesh, Babu V., Frost, Kathy F., Medina, Sarah J., Booth, Stephanie A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647949/
https://www.ncbi.nlm.nih.gov/pubmed/36352465
http://dx.doi.org/10.1186/s40478-022-01450-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9647949/
https://www.ncbi.nlm.nih.gov/pubmed/36352465
http://dx.doi.org/10.1186/s40478-022-01450-4

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