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An integrated in silico-in vitro approach for identifying therapeutic targets against osteoarthritis

BACKGROUND: Without the availability of disease-modifying drugs, there is an unmet therapeutic need for osteoarthritic patients. During osteoarthritis, the homeostasis of articular chondrocytes is dysregulated and a phenotypical transition called hypertrophy occurs, leading to cartilage degeneration...

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Detalles Bibliográficos
Autores principales:	Lesage, Raphaëlle, Ferrao Blanco, Mauricio N., Narcisi, Roberto, Welting, Tim, van Osch, Gerjo J. V. M., Geris, Liesbet
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648005/ https://www.ncbi.nlm.nih.gov/pubmed/36352408 http://dx.doi.org/10.1186/s12915-022-01451-8

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