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Dual genome-wide coding and lncRNA screens in neural induction of induced pluripotent stem cells
Human chromosomes are pervasively transcribed, but systematic understanding of coding and long noncoding RNA (lncRNA) genome function in cell differentiation is lacking. Using CRISPR interference (CRISPRi) in human induced pluripotent stem cells, we performed dual genome-wide screens—assessing 18,90...
Autores principales: | Wu, David, Poddar, Aunoy, Ninou, Elpiniki, Hwang, Elizabeth, Cole, Mitchel A., Liu, S. John, Horlbeck, Max A., Chen, Jin, Replogle, Joseph M., Carosso, Giovanni A., Eng, Nicolas W.L., Chang, Jonghoon, Shen, Yin, Weissman, Jonathan S., Lim, Daniel A. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648144/ https://www.ncbi.nlm.nih.gov/pubmed/36381608 http://dx.doi.org/10.1016/j.xgen.2022.100177 |
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