Catch-enrich-release approach for amine-containing natural products

Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the spec...

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Detalles Bibliográficos
Autores principales: Müller, Michelle Jessy, Dorst, Andrea, Paulus, Constanze, Khan, Imran, Sieber, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2022
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648515/
https://www.ncbi.nlm.nih.gov/pubmed/36264220
http://dx.doi.org/10.1039/d2cc04905h
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author Müller, Michelle Jessy
Dorst, Andrea
Paulus, Constanze
Khan, Imran
Sieber, Simon
author_facet Müller, Michelle Jessy
Dorst, Andrea
Paulus, Constanze
Khan, Imran
Sieber, Simon
author_sort Müller, Michelle Jessy
collection PubMed
description Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products.
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spelling pubmed-96485152022-12-20 Catch-enrich-release approach for amine-containing natural products Müller, Michelle Jessy Dorst, Andrea Paulus, Constanze Khan, Imran Sieber, Simon Chem Commun (Camb) Chemistry Amine-containing natural products are an important class of therapeutic compounds. Herein, we report a chemoselective approach to catch and enrich amine-containing natural products, and release them as underivatized compounds. The strategy exploits the selectivity of the enzyme legumain for the specific release of amine-containing natural products. The Royal Society of Chemistry 2022-10-17 /pmc/articles/PMC9648515/ /pubmed/36264220 http://dx.doi.org/10.1039/d2cc04905h Text en This journal is © The Royal Society of Chemistry https://creativecommons.org/licenses/by-nc/3.0/
spellingShingle Chemistry
Müller, Michelle Jessy
Dorst, Andrea
Paulus, Constanze
Khan, Imran
Sieber, Simon
Catch-enrich-release approach for amine-containing natural products
title Catch-enrich-release approach for amine-containing natural products
title_full Catch-enrich-release approach for amine-containing natural products
title_fullStr Catch-enrich-release approach for amine-containing natural products
title_full_unstemmed Catch-enrich-release approach for amine-containing natural products
title_short Catch-enrich-release approach for amine-containing natural products
title_sort catch-enrich-release approach for amine-containing natural products
topic Chemistry
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648515/
https://www.ncbi.nlm.nih.gov/pubmed/36264220
http://dx.doi.org/10.1039/d2cc04905h
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AT siebersimon catchenrichreleaseapproachforaminecontainingnaturalproducts

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