CD169(+) macrophages orchestrate plasmacytoid dendritic cell arrest and retention for optimal priming in the bone marrow of malaria-infected mice

Plasmacytoid dendritic cells (pDCs) are the most potent producer of type I interferon (IFN), but how pDC is primed in vivo is poorly defined. Using a mouse model of severe malaria, we have previously established that upon priming by CD169(+) macrophages (MPs), pDC initiates type I IFN-I secretion in...

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Detalles Bibliográficos
Autores principales: Moore-Fried, Jamie, Paul, Mahinder, Jing, Zhixin, Fooksman, David, Lauvau, Gregoire
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Immunology and Inflammation
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648966/
https://www.ncbi.nlm.nih.gov/pubmed/36278864
http://dx.doi.org/10.7554/eLife.78873

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648966/
https://www.ncbi.nlm.nih.gov/pubmed/36278864
http://dx.doi.org/10.7554/eLife.78873

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