Quantifying how post-transcriptional noise and gene copy number variation bias transcriptional parameter inference from mRNA distributions

Transcriptional rates are often estimated by fitting the distribution of mature mRNA numbers measured using smFISH (single molecule fluorescence in situ hybridization) with the distribution predicted by the telegraph model of gene expression, which defines two promoter states of activity and inactiv...

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Detalles Bibliográficos
Autores principales: Fu, Xiaoming, Patel, Heta P, Coppola, Stefano, Xu, Libin, Cao, Zhixing, Lenstra, Tineke L, Grima, Ramon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2022
Materias:
Computational and Systems Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648968/
https://www.ncbi.nlm.nih.gov/pubmed/36250630
http://dx.doi.org/10.7554/eLife.82493

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9648968/
https://www.ncbi.nlm.nih.gov/pubmed/36250630
http://dx.doi.org/10.7554/eLife.82493

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