Challenges associated with test dose pharmacokinetic predictions of high dose melphalan exposure in patients with multiple myeloma

AIM: To evaluate the accuracy of melphalan test dose pharmacokinetic (PK) predictions of the subsequent high dose (HDM) area under the concentration-versus-time curve (AUC) and to identify sources of prediction error (PE). METHODS: A prospective multicentre PK study was conducted in 40 myeloma patie...

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Detalles Bibliográficos
Autores principales: Nath, Christa Ellen, Grigg, Andrew, Rosser, Sebastian P. A., Estell, Jane, Newman, Elizabeth, Tiley, Campbell, Ramanathan, Sundra, Ho, Shir Jing, Larsen, Stephen, Gibson, John, Presgrave, Peter, Shaw, Peter John, Trotman, Judith
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649448/
https://www.ncbi.nlm.nih.gov/pubmed/36205743
http://dx.doi.org/10.1007/s00228-022-03396-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649448/
https://www.ncbi.nlm.nih.gov/pubmed/36205743
http://dx.doi.org/10.1007/s00228-022-03396-x

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