Knockout of ABC transporters by CRISPR/Cas9 contributes to reliable and accurate transporter substrate identification for drug discovery

It is essential to explore the relationship between drugs and transporters in the process of drug development. Strong background signals in nonhuman MDCK or LLC-PK1 cells and overlapping interference of inhibitors or RNAi in human Caco-2 cells mean that an ideal alternative could be to knock out spe...

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Detalles Bibliográficos
Autores principales: Feng, Dongyan, Zhong, Guorui, Zuo, Qingxia, Wan, Yanbin, Xu, Wanqing, He, Changsheng, Lin, Cailing, Huang, Dongchao, Chen, Feng, Huang, Lizhen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649518/
https://www.ncbi.nlm.nih.gov/pubmed/36386127
http://dx.doi.org/10.3389/fphar.2022.1015940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649518/
https://www.ncbi.nlm.nih.gov/pubmed/36386127
http://dx.doi.org/10.3389/fphar.2022.1015940

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