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Autophagy activation can partially rescue proteasome dysfunction‐mediated cardiac toxicity

The ubiquitin–proteasome pathway and its functional interplay with other proteostatic and/or mitostatic modules are crucial for cell viability, especially in post‐mitotic cells like cardiomyocytes, which are constantly exposed to proteotoxic, metabolic, and mechanical stress. Consistently, treatment...

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Detalles Bibliográficos
Autores principales: Papanagnou, Eleni‐Dimitra, Gumeni, Sentiljana, Sklirou, Aimilia D., Rafeletou, Alexandra, Terpos, Evangelos, Keklikoglou, Kleoniki, Kastritis, Efstathios, Stamatelopoulos, Kimon, Sykiotis, Gerasimos P., Dimopoulos, Meletios A., Trougakos, Ioannis P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649605/
https://www.ncbi.nlm.nih.gov/pubmed/36259256
http://dx.doi.org/10.1111/acel.13715