Rosa26-LSL-dCas9-VPR: a versatile mouse model for tissue specific and simultaneous activation of multiple genes for drug discovery

Transgenic animals with increased or abrogated target gene expression are powerful tools for drug discovery research. Here, we developed a CRISPR-based Rosa26-LSL-dCas9-VPR mouse model for targeted induction of endogenous gene expression using different Adeno-associated virus (AAV) capsid variants f...

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Detalles Bibliográficos
Autores principales: Pakalniškytė, Dalia, Schönberger, Tanja, Strobel, Benjamin, Stierstorfer, Birgit, Lamla, Thorsten, Schuler, Michael, Lenter, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649745/
https://www.ncbi.nlm.nih.gov/pubmed/36357523
http://dx.doi.org/10.1038/s41598-022-23127-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649745/
https://www.ncbi.nlm.nih.gov/pubmed/36357523
http://dx.doi.org/10.1038/s41598-022-23127-7

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