The deubiquitinase OTUD1 regulates immunoglobulin production and proteasome inhibitor sensitivity in multiple myeloma

Serum monoclonal immunoglobulin (Ig) is the main diagnostic factor for patients with multiple myeloma (MM), however its prognostic potential remains unclear. On a large MM patient cohort (n = 4146), we observe no correlation between serum Ig levels and patient survival, while amount of intracellular...

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Detalles Bibliográficos
Autores principales: Vdovin, Alexander, Jelinek, Tomas, Zihala, David, Sevcikova, Tereza, Durech, Michal, Sahinbegovic, Hana, Snaurova, Renata, Radhakrishnan, Dhwani, Turi, Marcello, Chyra, Zuzana, Popkova, Tereza, Venglar, Ondrej, Hrdinka, Matous, Hajek, Roman, Simicek, Michal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649770/
https://www.ncbi.nlm.nih.gov/pubmed/36357400
http://dx.doi.org/10.1038/s41467-022-34654-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649770/
https://www.ncbi.nlm.nih.gov/pubmed/36357400
http://dx.doi.org/10.1038/s41467-022-34654-2

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