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Wnt-pathway inhibitors with selective activity against triple-negative breast cancer: From thienopyrimidine to quinazoline inhibitors

The Wnt-pathway has a critical role in development and tissue homeostasis and has attracted increased attention to develop anticancer drugs due to its aberrant activation in many cancers. In this study, we identified a novel small molecule series with a thienopyrimidine scaffold acting as a downstre...

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Detalles Bibliográficos
Autores principales: Boudou, Cédric, Mattio, Luce, Koval, Alexey, Soulard, Valentin, Katanaev, Vladimir L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9649909/
https://www.ncbi.nlm.nih.gov/pubmed/36386148
http://dx.doi.org/10.3389/fphar.2022.1045102