Miltefosine as a PPM1A activator improves AD-like pathology in mice by alleviating tauopathy via microglia/neurons crosstalk

Alzheimer's disease (AD) is a progressively neurodegenerative disease without effective treatment. Here, we reported that the levels of expression and enzymatic activity of phosphatase magnesium-dependent 1A (PPM1A) were both repressed in brains of AD patient postmortems and 3 × Tg-AD mice, and...

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Detalles Bibliográficos
Autores principales: Lv, Jianlu, Shen, Xingyi, Shen, Xinya, Li, Xiaoqian, Jin, Zhuoying, Ouyang, Xingnan, Lu, Jian, Zhu, Danyang, Wang, Jiaying, Shen, Xu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Full Length Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650016/
https://www.ncbi.nlm.nih.gov/pubmed/36388134
http://dx.doi.org/10.1016/j.bbih.2022.100546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650016/
https://www.ncbi.nlm.nih.gov/pubmed/36388134
http://dx.doi.org/10.1016/j.bbih.2022.100546

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