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Advances in antitumor research of CA-4 analogs carrying quinoline scaffold
Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the cis double bond configuration and the 3,4,5-trimethoxy group on the A ring were important factors to maintain th...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650302/ https://www.ncbi.nlm.nih.gov/pubmed/36385996 http://dx.doi.org/10.3389/fchem.2022.1040333 |
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author | Wang, Chao Chang, Jing Yang, Shanbo Shi, Lingyu Zhang, Yujing Liu, Wenjing Meng, Jingsen Zeng, Jun Zhang, Renshuai Xing, Dongming |
author_facet | Wang, Chao Chang, Jing Yang, Shanbo Shi, Lingyu Zhang, Yujing Liu, Wenjing Meng, Jingsen Zeng, Jun Zhang, Renshuai Xing, Dongming |
author_sort | Wang, Chao |
collection | PubMed |
description | Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the cis double bond configuration and the 3,4,5-trimethoxy group on the A ring were important factors to maintain the activity of CA-4. Therefore, starting from this condition, chemists modified the double bond and also substituted 3,4,5-trimethoxyphenyl with various heterocycles, resulting in a new generation of CA-4 analogs such as chalcone, Flavonoid derivatives, indole, imidazole, etc. Quinoline derivatives have strong biological activity and have been sought after by major researchers for their antitumor activity in recent years. This article reviews the research progress of novel CA-4 containing quinoline analogs in anti-tumor from 1992 to 2022 and expounds on the pharmacological mechanisms of these effective compounds, including but not limited to apoptosis, cell cycle, tubulin polymerization inhibition, immune Fluorescence experiments, etc., which lay the foundation for the subsequent development of CA-4 containing quinoline analogs for clinical use. |
format | Online Article Text |
id | pubmed-9650302 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-96503022022-11-15 Advances in antitumor research of CA-4 analogs carrying quinoline scaffold Wang, Chao Chang, Jing Yang, Shanbo Shi, Lingyu Zhang, Yujing Liu, Wenjing Meng, Jingsen Zeng, Jun Zhang, Renshuai Xing, Dongming Front Chem Chemistry Combretastatin A-4 (CA-4) is a potent inhibitor of tubulin polymerization and a colchicine binding site inhibitor (CBSI). The structure-activity relationship study of CA-4 showed that the cis double bond configuration and the 3,4,5-trimethoxy group on the A ring were important factors to maintain the activity of CA-4. Therefore, starting from this condition, chemists modified the double bond and also substituted 3,4,5-trimethoxyphenyl with various heterocycles, resulting in a new generation of CA-4 analogs such as chalcone, Flavonoid derivatives, indole, imidazole, etc. Quinoline derivatives have strong biological activity and have been sought after by major researchers for their antitumor activity in recent years. This article reviews the research progress of novel CA-4 containing quinoline analogs in anti-tumor from 1992 to 2022 and expounds on the pharmacological mechanisms of these effective compounds, including but not limited to apoptosis, cell cycle, tubulin polymerization inhibition, immune Fluorescence experiments, etc., which lay the foundation for the subsequent development of CA-4 containing quinoline analogs for clinical use. Frontiers Media S.A. 2022-10-28 /pmc/articles/PMC9650302/ /pubmed/36385996 http://dx.doi.org/10.3389/fchem.2022.1040333 Text en Copyright © 2022 Wang, Chang, Yang, Shi, Zhang, Liu, Meng, Zeng, Zhang and Xing. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Wang, Chao Chang, Jing Yang, Shanbo Shi, Lingyu Zhang, Yujing Liu, Wenjing Meng, Jingsen Zeng, Jun Zhang, Renshuai Xing, Dongming Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title | Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title_full | Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title_fullStr | Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title_full_unstemmed | Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title_short | Advances in antitumor research of CA-4 analogs carrying quinoline scaffold |
title_sort | advances in antitumor research of ca-4 analogs carrying quinoline scaffold |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650302/ https://www.ncbi.nlm.nih.gov/pubmed/36385996 http://dx.doi.org/10.3389/fchem.2022.1040333 |
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