Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

BACKGROUND: Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial cells, which is a potent chemoattractant for neutrophils. However, the patholo...

Descripción completa

Detalles Bibliográficos
Autores principales: Yuliani, Fara Silvia, Chen, Jing-Yun, Cheng, Wen-Hao, Wen, Heng-Ching, Chen, Bing-Chang, Lin, Chien-Huang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2022
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650896/
https://www.ncbi.nlm.nih.gov/pubmed/36369000
http://dx.doi.org/10.1186/s12929-022-00877-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650896/
https://www.ncbi.nlm.nih.gov/pubmed/36369000
http://dx.doi.org/10.1186/s12929-022-00877-0

Ejemplares similares