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Thrombin induces IL-8/CXCL8 expression by DCLK1-dependent RhoA and YAP activation in human lung epithelial cells

BACKGROUND: Doublecortin-like kinase 1 (DCLK1) has been recognized as a marker of cancer stem cell in several malignancies. Thrombin is crucial in asthma severity as it can promote IL-8/CXCL8 production in lung epithelial cells, which is a potent chemoattractant for neutrophils. However, the patholo...

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Detalles Bibliográficos
Autores principales:	Yuliani, Fara Silvia, Chen, Jing-Yun, Cheng, Wen-Hao, Wen, Heng-Ching, Chen, Bing-Chang, Lin, Chien-Huang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2022
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9650896/ https://www.ncbi.nlm.nih.gov/pubmed/36369000 http://dx.doi.org/10.1186/s12929-022-00877-0

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