Safety, Tolerability, and Parasite Clearance Kinetics in Controlled Human Malaria Infection after Direct Venous Inoculation of Plasmodium falciparum Sporozoites: A Model for Evaluating New Blood-Stage Antimalarial Drugs

Plasmodium falciparum sporozoite (PfSPZ) direct venous inoculation (DVI) using cryopreserved, infectious PfSPZ (PfSPZ Challenge [Sanaria, Rockville, Maryland]) is an established controlled human malaria infection model. However, to evaluate new chemical entities with potential blood-stage activity,...

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Detalles Bibliográficos
Autores principales: Chughlay, M. Farouk, Chalon, Stephan, El Gaaloul, Myriam, Gobeau, Nathalie, Möhrle, Jörg J., Berghmans, Pieter-Jan, Van Leuven, Katrin, Marx, Michael W., Rosanas-Urgell, Anna, Flynn, Julia, Escoffier, Emilie, Izquierdo-Juncàs, Daniel, Jansen, Bastiaan, Mitov, Venelin, Kümmel, Anne, Van Geertruyden, Jean-Pierre, Barnes, Karen I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The American Society of Tropical Medicine and Hygiene 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651526/
https://www.ncbi.nlm.nih.gov/pubmed/36037868
http://dx.doi.org/10.4269/ajtmh.21-1297

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651526/
https://www.ncbi.nlm.nih.gov/pubmed/36037868
http://dx.doi.org/10.4269/ajtmh.21-1297

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