Fragment-based computational design of antibodies targeting structured epitopes

De novo design methods hold the promise of reducing the time and cost of antibody discovery while enabling the facile and precise targeting of predetermined epitopes. Here, we describe a fragment-based method for the combinatorial design of antibody binding loops and their grafting onto antibody sca...

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Detalles Bibliográficos
Autores principales: Aguilar Rangel, Mauricio, Bedwell, Alice, Costanzi, Elisa, Taylor, Ross J., Russo, Rosaria, Bernardes, Gonçalo J. L., Ricagno, Stefano, Frydman, Judith, Vendruscolo, Michele, Sormanni, Pietro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Physical and Materials Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651861/
https://www.ncbi.nlm.nih.gov/pubmed/36367941
http://dx.doi.org/10.1126/sciadv.abp9540

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651861/
https://www.ncbi.nlm.nih.gov/pubmed/36367941
http://dx.doi.org/10.1126/sciadv.abp9540

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