Caspase-8 inactivation drives autophagy-dependent inflammasome activation in myeloid cells

Caspase-8 activity controls the switch from cell death to pyroptosis when apoptosis and necroptosis are blocked, yet how caspase-8 inactivation induces inflammasome assembly remains unclear. We show that caspase-8 inhibition via IETD treatment in Toll-like receptor (TLR)–primed Fadd(−/−)Ripk3(−/−) m...

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Detalles Bibliográficos
Autores principales: Wu, Yung-Hsuan, Mo, Shu-Ting, Chen, I-Ting, Hsieh, Fu-Yi, Hsieh, Shie-Liang, Zhang, Jinake, Lai, Ming-Zong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2022
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651862/
https://www.ncbi.nlm.nih.gov/pubmed/36367942
http://dx.doi.org/10.1126/sciadv.abn9912

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9651862/
https://www.ncbi.nlm.nih.gov/pubmed/36367942
http://dx.doi.org/10.1126/sciadv.abn9912

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